李辉莹，1988年生，妇产科学博士，硕士生导师。湖北省病理生理学会生殖医学专业委员会第一届学会委员。2009年毕业于中南大学，获理学学士学位。2012年毕业于中南大学，获理学硕士学位。2022年毕业于华中科技大学同济医学院生殖健康研究所，获医学博士学位。
联系方式：huiying880601@ctgu.edu.cn
研究方向：女性生殖内分泌疾病，女性生殖衰老。
招收临床医学或基础医学学术型研究生。
承担主要研究项目：
1. 国家自然科学基金委员会青年科学基金项目（C类）[原青年科学基金项目]，82500964，HIGD1A通过C1QBP调控线粒体功能在卵巢功能减退中的机制研究，2026-01-01 至 2028-12-31，30万元，在研，主持。
2. 湖北省自然科学基金青年项目，2024AFB231，HIGD1A/FOXO通路在环磷酰胺所致卵巢损伤中的保护作用及机制，2024-03至2026-02，8万元，在研，主持。
代表性论著：
1 H. Li, S. Cai, H. Mu, T. Chang, X. Wang, T. Tang, T. Dong, Y. Zhang, L. Zhang, H. Li, L. Zhou, and W. Xiang. HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway. Adv Sci (Weinh), 2025: e03828.
2 H. Li, X. Wang, H. Mu, Q. Mei, Y. Liu, Z. Min, L. Zhang, P. Su, and W. Xiang. Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis. Int J Biol Sci, 2022. 18(3): 1008-1021.
3 H. Li, T. Chang, H. Mu, and W. Xiang. Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome. J Ovarian Res, 2022. 15(1): 42.
4 H. Li, W. Xiang, and H. L. Feng. Oocyte cryopreservation in women after childhood and adolescent cancer. Fertil Steril, 2021. 116(4): 1096-1097.
5 X. Wang, H. Li, H. Mu, S. Zhang, Y. Li, X. Han, L. Zhang, and W. Xiang. Melatonin improves the quality of rotenone-exposed mouse oocytes through association with histone modifications. Ecotoxicol Environ Saf, 2023. 262: 115186.
6 L. Xie, H. Li, M. Xiao, N. Chen, X. Zang, Y. Liu, H. Ye, and C. Tang. Epigenetic insights into Fragile X Syndrome. Front Cell Dev Biol, 2024. 12: 1432444.
7 H. Mu, H. Li, Y. Liu, X. Wang, Q. Mei, and W. Xiang. N6-Methyladenosine Modifications in the Female Reproductive System: Roles in Gonad Development and Diseases. Int J Biol Sci, 2022. 18(2): 771-782.
8 Q. Mei, H. Li, Y. Liu, X. Wang, and W. Xiang. Advances in the study of CDC42 in the female reproductive system. J Cell Mol Med, 2022. 26(1): 16-24.
9 X. Wang, J. Yang, H. Li, H. Mu, L. Zeng, S. Cai, P. Su, H. Li, L. Zhang, and W. Xiang. miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation. Redox Biol, 2023. 62: 102684.
10 L. Wang, Q. Mei, Q. Xie, H. Li, P. Su, L. Zhang, K. Li, D. Ma, G. Chen, J. Li, and W. Xiang. A comparative study of Mesenchymal Stem Cells transplantation approach to antagonize age-associated ovarian hypofunction with consideration of safety and efficiency. J Adv Res, 2022. 38: 245-259.
11 H. Mu, S. Cai, X. Wang, H. Li, L. Zhang, H. Li, and W. Xiang. RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m(6)A-dependent manner. Redox Biol, 2022. 57: 102492.
12 H. Cai, T. Chang, Y. Li, Y. Jia, H. Li, M. Zhang, P. Su, L. Zhang, and W. Xiang. Circular DDX10 is associated with ovarian function and assisted reproductive technology outcomes through modulating the proliferation and steroidogenesis of granulosa cells. Aging (Albany NY), 2021. 13(7): 9592-9612.
13 Y. Liu, Q. Shen, H. Li, W. Xiang, and L. Zhang. Cell-free mitochondrial DNA increases granulosa cell apoptosis and reduces aged oocyte blastocyst development in the mouse. Reprod Toxicol, 2020. 98: 278-285.
