博士，教授，中华医学会眼科学分会青光眼学组委员，中国医师协会眼科医师分会青光眼专业委员会委员，美国Wills眼科医院research fellow，新加坡国立眼科中心访问学者，湖北省有突出贡献中青年专家，湖北省医学青年拔尖人才，宜昌市十大杰出人才，湖北省毕业后教育专家委员会眼科专业组副组长、湖北省医学会眼科学分会常委，湖北省医师协会眼科医师分会神经眼科学组副组长，国家自然科学基金同行评审专家。

承担主要研究项目：

1、湖北省自然科学基金面上项目：视网膜小胶质细胞在青光眼视神经损害中的作用机制；

2、湖北省卫计委青年人才项目：RGD多肽水凝胶的研制及其在青光眼造瘘术后抗瘢痕化的作用；

3、国家自然科学基金面上项目：RGD多肽水凝胶的研制及其在青光眼滤过术后抗瘢痕化的作用机制；

4、横向项目：5-FU RGD多肽水凝胶控释系统在青光眼滤过术后抗瘢痕化中的作用；

5、国家重点实验室开放项目：多肽凝胶控释系统研究

主要研究成果:

在科研方面一直致力于青光眼术后抗瘢痕及视神经保护的机制研究，在新型生物材料RGD多肽水凝胶及抗代谢药物缓释系统方面有重大研究发现；对青光眼滤过道瘢痕化通路、青光眼视神经保护药物方面进行了系列研究。

1、视网膜小胶质细胞在青光眼视神经损害中的作用

2、改良青光眼滤过术后巩膜瓣、结膜瓣可调节缝线技术对青光眼滤过术后抗瘢痕化作用

3、首次实现Toll样受体4（TLR4）信号通路在眼部的抗瘢痕化应用

4、RGD多肽水凝胶合成

5、RGD多肽水凝胶载药后缓释系统的构建

6、鼠尾草酸对青光眼视神经保护作用

代表性论著

1．《Wills临床眼科彩色图谱及精要:青光眼》，第二版，主编、主译，天津科学翻译出版有限公司，2018

2．《Wills临床眼科彩色图谱及精要:青光眼》，第三版，主编、主译，天津科学翻译出版有限公司，2022

3．《世界青光眼共识丛书:儿童青光眼》，参编，人民卫生出版社，2017

4．《世界青光眼共识丛书:开角型青光眼的诊断》，参编，人民卫生出版社，2018

5．《亚太青光眼指南》，参编，人民卫生出版社，2019

6．《中国青光眼指南》，参编，人民卫生出版社，2023

7．Lufan Li, Nan Zhang, Xiaoqin Wang, Liang Liang*, Min Ke, et al. Changes in eye axis length and corneal curvature in central China from the perspective of birth year, Eye (Lond) . 2025 Feb 6. doi: 10.1038/s41433-025-03652-1.

8．胡昊,梁亮.正常眼压青光眼相关基因的研究进展[J/OL].中山大学学报(医学科学版),1-10[2025-12-03].https://doi.org/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0604.

9．Lv Y, Qin M, Jiang RP, Zong FF, Wu X, Wu KL, Liang L*. RGD peptide hydrogel downregulates mechanosignal YAP to inhibit postoperative scarring[J]. Acta Biomater, 2025, 199: 132-141.

10．Song S, Wu X, Ni S, Jia DD, Tang JJ, Ran JB, Liang L*. Treating bacterial keratitis during sleep through placing hydrogel beads with sustained tobramycin/baicalin delivery capability at the palpebra inferior[J]. J Mater Chem B, 2026, 14(4): 1272-1285.

11．Wu X, Wu KL, Ni SB, Song SY, Jia DD, Tang JJ, Ran JB*, Liang L*. Inhibiting postoperative fibrosis in glaucoma filtration surgery through porous PLLA/RGD membrane mediated local/sustained delivery of mitomycin C[J]. Transl Vis Sci Technol, 2025, 14(12): 1.

12．胡昊,贾大东,王旖瑶,梁亮*.基因在原发性开角型青光眼中的研究进展[J].国际眼科杂志,2025,25(11):1764-1770.

13．Jia DD, Xiao QA, Hu H, Wu KL, Ran JB, Liang L. Identification of novel drug targets for primary open angle glaucoma and its potential side-effects by human plasma proteome. Int J Ophthalmol. 2025 Aug 18;18(8):1470-1477. doi: 10.18240/ijo.2025.08.07. PMID: 40827287; PMCID: PMC12311459.

14．贾大东，胡昊，梁亮*．DNA 甲基化在青光眼中的研究进展[J/OL]．生命科学. 2024, https://link.cnki.net/urlid/31.1600.q.20241216.1744.002

15．Fei-Fei Zong, Da-Dong Jia, Hao Hu, Shi-Yi Song, Ru-Weng Wang, Liang Liang*, New perspectives on DNA methylation modifications in ocular diseases, Int J Ophthalmol, Vol. 18, No. 2, Feb. 18, 2025

16．Binlin Chen, Licheng Liang, Dadong Jia, Mian Qin, Shuai Liu, Yao Lv, Ruping Jiang and Liang Liang*, Inhibitory effect of RGD peptide hydrogel on inflammation and angiogenesis in vitro[J]. Journal of Biomaterials Applications, 2024, Vol. 0(0) 1–11.DOI: 10.1177/08853282241296520

17．Ruping Jiang, Yao Lv, Binlin Chen, Xia Wu, Yuan Zou, Liang Liang*, Antioxidant effect of gallic acid on retinal ganglion cells in glaucoma model. Sci Rep 2024 Jun 28;14(1):14907.doi: 10.1038/s41598-024-65965-73

18．Shanshan Han, Qiong Wang , Meiqi Cheng , Yue Hu, Pei Liu, Wanle Hou, Liang Liang*,The effects of ush2a gene knockout on vesicle transport in photoreceptors. Gene,https://doi.org/10.1016/j.gene.2023.147885.

19．Wu P, Wang Z, Liang L*, Chen B, Xu N. Characteristics of Mitomycin C-Loaded Peptide Hydrogel In Vitro and Antiscarring Effects in Rat Ocular Injury Model. J Ocul Pharmacol Ther. 2023 Feb 1. doi: 10.1089/jop.2022.0102.

20．Qiang Liu, Na Huang, Anni Li, Yuanhong Zhou, Liang Liang, Xinyu Song, Zhanqiu Yang, Xiaolin Zhou. Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19. Medicine (Baltimore), 2021 Feb 12;100(6):e24544.

21．Zhang H, Liang L*, Huang R, Wu P, He L.Comparison of inflammatory cytokines levels in the aqueous humor with diabetic retinopathy. Int Ophthalmol. 2020 Oct;40(10):2763-2769. doi: 10.1007/s10792-020-01463-9. Epub 2020 Jun 15.

22．Zhang HJ, Huang R, Liang L*, Zhou F, Wu P, Chen XY. Vision loss as the initial presentation during primary pulmonary hypertension treatment. Int J Ophthalmol. 2021 Sep 18;14(9):1460-1462.

23．Zhao CC, Zhu L, Wu Z, Yang R, Xu N, Liang L*. Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation. Regen Biomater. 2020 Feb;7(1):99-107.

24．Chen B, Wu P, Liang L*, Zhao C, Wang Z, He L, Zhang R, Xu N.Inhibited effect of an RGD peptide hydrogel on the expression of β1-integrin, FAK, and Akt in Tenon's capsule fibroblasts. J Biomed Mater Res B Appl Biomater. 2021 Nov;109(11):1857-1865.

25．Jin J, Liang L, Jin K, Zhang HJ, Liu R, Shen Y.Associations Between Fundus Types and Clinical Manifestations in Patients with RDH12 Gene Mutations. Brain Topogr. 2022 Jul;35(4):525-535.

26．Kang Zhang, Xiaohong Liu, Jun Shen, Zhihuan Li, Ye Sang, Liang Liang*, et al. Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements and Prognosis of COVID-19 Pneumonia Using Computed Tomography. Cell. DOI: 10.1016/j.cell.2020.04.045

27．Liang Liang*, He Liye, Zhu Mengnan, Chen Baoji, Xiao Changyi, Protective effects of carnosic acid on retinal ganglion cells in acute ocular hypertension rats. International Ophthalmology.2020 Apr 10.

28．Ping Wu, Liang Liang*, ChunBao Chen, ShengQiong Nie, A child confirmed COVID-19 with only symptoms of conjunctivitis and eyelid dermatitis, Graefes Arch Clin Exp Ophthalmol, 24 April 2020, Published Online.

29．Ping Wu, Fang Duan, Chunhua Luo, Qiang Liu, Xingguang Qu, Liang Liang*, Kaili Wu, Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019(COVID-19) in Hubei, China, JAMA Ophthalmology, 2020

30．Liang Liang*, Wu Ping, There may be virus in conjunctival secretion of patients with COVID-19, Acta Ophthalmol. 2020 Mar 18.

31．Liang Liang*, Zhu Mengnan, Chen Baoji,Wang Zeng,He Liye,Zhang Ran, Inhibitive effect of TAK-242 on Tenon's capsule fibroblasts proliferation in rat eyes.Int J Ophthalmol. 2019 Nov 18;12(11):1699-1707.

32．Chen Z, Chen J, Zhou J, Lei F, Zhou F, Qin JJ，Liang Liang, et al. A risk score based on baseline risk factors for predicting mortality in COVID-19 patients.Curr Med Res Opin. 2021 Jun;37(6):917-927.

33．Chen-Chen Zhao, Lian Zhu, Zheng Wu, Rui Yang, Na Xu, and Liang Liang*. Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation. Regenerative Biomaterials. 2019,11,publish online.

34．Liang Liang*, Zhang Ran, He Liye. Corneal Hysteresis and Glaucoma. Int Ophthalmol, 2018 Sep 5.