姓名：陈静
职称：副教授
研究学科：医学、药学
主要研究方向：神经精神药理
Email：chenjing@ctgu.edu.cn
个人简况：
陈静，女，1979年9月生，医学博士，副教授，硕士研究生导师，肯塔基大学医学院访问学者，三峡大学健康医学院副院长。近年来主持省级科研项目2项，厅局级项目1项，横向项目1项，参与国家自然科学基金项目4项，发表科研论文30余篇，主编专著1部，获批授权专利1项。
学习经历：
2014.9-2017.7 武汉生物制品研究所，免疫学，博士
2012.12-2013.6 University of Kentucky Medical School（肯塔基大学医学院），访问学者
2002.9-2005.7 中山大学医学院，生理学，硕士
1997.9-2002.6 三峡大学医学院，临床医学，学士
近期开展的科研工作：
近期围绕药物的抗脑缺血作用及机制等研究领域开展工作。
近五年主持或者承担主要科研项目：
（1）湖北省自然科学基金，创新发展联合基金，2024AFD199，基于线粒体凋亡信号通路探讨香椿子多酚减轻脑缺血损伤的机制，2024.3至2026.3，在研，主持
（2）宜昌市科技局，医疗卫生科研项目， A22-2-068，可乐定通过调节NMDA受体NR3亚基对脑缺血再灌注损伤发挥神经保护作用， 2022.4 至 2024.4，结题，主持
（3）湖北省自然科学基金，面上项目，2019CFC865，柯萨奇病毒A6 病毒样颗粒的免疫原性及保护性研究，2019.1至2020.12，结题，主持
（4）国家自然科学基金委员会， 面上项目，82073824，NR2B受体与HCN通道介导可乐定抗卒中后焦虑新的药理作用及其机制，2021-01至 2024-12，在研，参与
代表性论文：
(1) Zhi He, Bo-kai Yin, Ke Wang, Bo Zhao, Yue Chen, Zi-Cheng Li, Jing Chen. The alpha2-adrenergic receptor agonist clonidine protects against cerebral ischemia/reperfusion induced neuronal apoptosis in rats. Metabolic Brain Disease, 2024, DOI: 10.1007/s11011-024-01354-3.
(2) Jing Chen, Juan Zhang, Dan-Dan Yang, Zi-Cheng Li, Bo Zhao, Yue Chen, Zhi He. Clonidineameliorates cerebral ischemia–reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor. Metabolic Brain Disease, 2022, 37(6): 1829-1841
(3) CHEN Jing，LI Bo，LI Pengfei, etc. Preparation and Humoral Immunogenicity Analysis of Coxsackievirus A6 Virus⁃Like Particles. CHINESE JOURNAL OF VIROLOGY, 2020, 36(6): 1067-1074
(4) CHEN Jing，LI Bo，SHEN Shuo，FAN Yafei. Research Progress on COVID-19 Vaccine. CHINESE JOURNAL OF VIROLOGY, 2020, 36(4): 685-691
(5) Yan Zhu, Jin Chen, Chun Liang, Liang Zong, Jing Chen, Raleigh O. Jones, Hong-BoZhao, Connexin26 (GJB2) deficiency reduces active cochlearamplification leading to late-onset hearing loss. Neuroscience, 2015, 22(284): 719–729
(6) Jin Chen, Yan Zhu, Chun Liang, Jing Chen, Hong-Bo Zhao，Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing，Scientific Reports，2015, 5(10762):1-10
(7) Jing Chen, Hong-Bo Zhao. The role of an inwardly rectifying K+ channel (Kir4.1) in the inner ear and hearing loss. Neuroscience, 2014, 265: 137-146
(8) Jin Chen, Jing Chen, Yan Zhu, Chun Liang, Hong-Bo Zhao. Deafness induced by Connexin26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders. Biochemical and Biophysical Research Communications, 2014, 448(1): 28-32
(9) Xiao-Qing Tang, Chun-Tao Yang, Jing Chen, Wei-Lan Yin, Shao-Wen Tian, Bi Hu, Jian-qiang Feng, Yuan-Jian Li, Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells, Clin Exp Pharmacol Physiol, 2008, 35(2):180-186(IF: 2.092)
(10) Jing Chen, Xiao-Qing Tang, Jun-Li. Zhi, Yu Cui, Hui-Min. Yu, Er-Hu Tang, Jian-Qiang Feng, Pei-Xi Chen, Curcumin protects PC12 cells against 1-methyl-4- phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS- iNOS pathway. Apoptosis，2006，11(6)：943-953
(11) TANG Xiao-Qing, CHEN Jing, TANG Er-Hu, FENG Jian-Qiang, CHEN Pei-Xi, Hydrogen peroxide preconditioning protects PC12 cells against apoptosis induced by oxidative stress, Acta Physiologica Sinica, 2005, 57(2):211-216
(12) Tang XQ, Feng JQ, Chen J, etc. Protection of oxidative preconditioning against apoptosis induced by H2O2 in PC12 cells: mechanisms via MMP, ROS, and Bcl-2, Brain Res, 2005, 1057(1-2): 57-64
