
范致星,1989年8月生,医学博士,硕士生导师。2022年博士毕业于武汉大学,主要从事心血管疾病的基础与临床研究,以第一作者发表SCI论文20余篇,担任多个SCI期刊的青年编委和审稿专家。主持国家自然科学基金面上项目和青年基金项目各1项,湖北省自然科学基金面上项目1项,湖北省卫生健康委青年人才项目1项,主持英国UK Biobank项目1项,获得湖北省科技进步奖2项。
联系方式:fanzhixing@ctgu.edu.cn
研究方向:
1. 心血管疾病的基础和临床研究
2. 衰老相关性疾病的临床和公共卫生研究
3. 循证医学及系统评价
主持项目:
1. 国家自然科学基金面上项目(No. 82371597):NSUN2介导SPP1m5C修饰对衰老相关性房颤的影响及机制研究:
2. 国家自然科学基金青年基金项目(No.81800258):VSMCs源性外泌体miRNAs介导内皮损伤在糖尿病血管重构中的作用及机制研究;
3. 英国UK Biobank项目(No. 170605):Association analysis, causal inference, and modeling of genetic, environmental, lifestyle, and clinical determinants in the occurrence, progression, and prognosis of age-related diseases. (遗传、环境、生活方式和临床决定因素在衰老相关性疾病发生、进展和预后中的关联分析、因果推断和预测模型);
4. 湖北省自然科学基金一般面上项目(No.3.2023AFB609):RNA m5C甲基转移酶NSUN2通过SPP1介导线粒体功能障碍在衰老相关性房颤中的作用及机制;
5. 湖北省卫生健康委青年人才项目(No.WJ2023M150):ECs源性外泌体miRNAs对缺血再灌注心肌的多重保护作用及机制研究;
6. 宜昌市医疗卫生科研项目(No.A18-301-06):曲美他嗪对冠心病心绞痛患者NALP3的调控作用及临床预后评估
代表性论文:
1. Fan ZX, Yang CJ, Zhao CY, et al. Association Between Healthful Plant-Based Dietary Pattern and Obesity Trajectories and Future Cardiovascular Diseases in Middle-Aged and Elderly: A Prospective and Longitudinal Cohort Study. Mol Nutr Food Res, 2025, 69(4):e202400833.
2. Fan ZX, Yang J. NSUN2/PARP1 signaling axis: A potential mechanism for treating aging-associated atrial fibrillation. Int J Cardiol, 2025, 422:132993.
3. Fan ZX, Yang CJ, Qu XL, et al. Association of Oxidative Stress on Cognitive Function A Bidirectional Mendelian Randomisation Study. Mol Neurobiol, 2024 61(12):10551-10560.
4. Fan ZX, Yang CJ, Zhang J, et al. Trends and influence factors in the prevalence, awareness, treatment, and control of hypertension among US adults from 1999 to 2018. PLoS One, 2023, 18(9):e0292159.
5. Fan ZX, Huang YF, Wu JC, et al. Negative correlation between serum NLRP3 and the ratio of Treg/Th17 in patients with obstructive coronary artery disease. Rev Cardiovasc Med, 2022, 23(12): 1-6.
6. Fan ZX, Yang J, Yang CJ, et al. MicroRNA‑24 attenuates diabetic vascular remodeling by suppressing the NLRP3/caspase‑1/IL‑1β signaling pathway. Int J Mol Med,2020 ,45(5):1534-1542.
7. Fan ZX, Yang J, Zhang J, et al. Analysis of influencing factors related to elevated serum troponin I level for COVID-19 patients in Yichang, China. Cardiovasc Diagn Ther, 2020,10(4):678-686.
8. Yang CJ, Fan ZX (共一), Wu J, et al. The Diagnostic Value of Soluble ST2 in Heart Failure: A Meta-Analysis. Front Cardiovasc Med,2021,8:685904.
9. Yang J, Fan ZX (共一), Yang J, Ding J, Yang C, Chen L. MicroRNA-24 Attenuates Neointimal Hyperplasia in the Diabetic Rat Carotid Artery Injury Model by Inhibiting Wnt4 Signaling Pathway. Int J Mol Sci. 2016;17(6):765.
10. Fan ZX, Yang J. The role of microRNAs in regulating myocardial ischemia reperfusion injury. Saudi Med J. 2015, 36(7):787-93.